Inhibitory effect of alginic acids on hyaluronidase and on histamine release from mast cells

被引：60

作者：

Asada, M

Sugie, M

Inoue, M

Nakagomi, K

Hongo, S

Murata, K

Irie, S

Takeuchi, T

Tomizuka, N

Oka, S

机构：

[1] NATL INST BIOSCI & HUMAN TECHNOL, TSUKUBA, IBARAKI 305, JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV, TOYAMA 93001, JAPAN

[3] KIBUN FOOD CHEMIFA CO LTD, SAYAMA, SAITAMA 35013, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 06期

关键词：

alginic acid; uronic acid; inhibitor; hyaluronidase; mast cell degranulation;

D O I：

10.1271/bbb.61.1030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of various types of alginic acid consisting of L-guluronic acids (G) and D-mannuronic acids (M) on hyaluronidase and mast cell degranulation were examined. Alginic acid with an M/G ratio of 1.0 exhibited the strongest inhibition of both activities, the higher molecular weight alginic acids of 150 to 370 kDa being preferable in both cases, Esterification of the carboxyl residue enhanced the latter activity.

引用

页码：1030 / 1032

页数：3

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[2]

KAKEGAWA H, 1985, CHEM PHARM BULL, V33, P5079

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MORI T, 1953, ADV CARBOHYD CHEM, V8, P315

[4] STUDIES ON INHIBITORS OF RAT MAST-CELL DEGRANULATION PRODUCED BY MICROORGANISMS .1. SCREENING OF MICROORGANISMS, AND ISOLATION AND PHYSICOCHEMICAL PROPERTIES OF EUROCIDIN-C, EUROCIDIN-D AND EUROCIDIN-E [J].