Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight

被引：141

作者：

Baggio, Laurie L. ^{[1
]}

Drucker, Daniel J. ^{[1
]}

机构：

[1] Univ Toronto, Mt Sinai Hosp, Dept Med, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2014年 / 124卷 / 10期

关键词：

NON-INFERIORITY; OPEN-LABEL; GLP-1; LIRAGLUTIDE; APPETITE; HUMANS; AMIDE;

D O I：

10.1172/JCI78371

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The peptide hormone glucagon-like peptide-1 (GLP-1) enhances glucose-induced insulin secretion and inhibits both gastric emptying and glucagon secretion. GLP-1 receptor (GLP-1R) agonists control glycemia via glucose-dependent mechanisms of action and promote weight loss in obese and diabetic individuals. Nevertheless, the mechanisms and cellular targets transducing the weight loss effects remain unclear. Two recent studies in the JCI provide insight into the neurons responsible for this effect. Sisley et al. reveal that GLP-1R agonist-induced weight loss requires GLP-1Rs in the ENS, while Secher et al. reveal that a small peptide GLP-1R agonist penetrates the brain and activates a subset of GLP-1R-expressing neurons in the arcuate nucleus to produce weight loss. Together, these two studies elucidate pathways that inform strategies coupling GLP-1R signaling to control of body weight in patients with diabetes or obesity.

引用

页码：4223 / 4226

页数：4

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