Toxoplasma-induced autophagy A window into nutritional futile cycles in mammalian cells?

被引：9

作者：

Orlofsky, Amos ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA

来源：

AUTOPHAGY | 2009年 / 5卷 / 03期

基金：

美国国家卫生研究院;

关键词：

toxoplasma; parasites; autophagy; futile cycles; protein metabolism; mTOR; amino acids; APICOMPLEXAN PARASITES; AMINO-ACIDS; PROTEINS; VACUOLE;

D O I：

10.4161/auto.5.3.7807

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The regulation and function of autophagy in response to metabolic signals is not yet well understood. A recent study from our laboratory indicates that an intracellular parasite, Toxoplasma gondii, derives nutritive benefit from the upregulation of host cell autophagy. We discuss this and related findings suggesting that autophagy in infected cells functions as part of a metabolic futile cycle. The hypothesis is presented that endogenous autophagy-based futile cycles may operate in normal mammalian cells, providing a substrate for manipulation by pathogens.

引用

页码：404 / 406

页数：3

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