Macrophage-enhanced germination of Bacillus anthracis endospores requires gerS

被引：51

作者：

Ireland, JAW

Hanna, PC

机构：

[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

[2] Duke Univ, Med Ctr, Dept Microbiol, Durham, NC 27710 USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 10期

关键词：

D O I：

10.1128/IAI.70.10.5870-5872.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Germination of Bacillus anthracis Sterne and plasmidless Delta-Sterne endospores was dramatically enhanced in RAW264.7 macrophage-like cells, while germination of nonpathogenic Bacillus endospores was not. Elimination of gerS, a germinant receptor locus, caused a complete loss of cell-enhanced germination, implicating gerS in the breaking of endospore dormancy in vivo.

引用

收藏

页码：5870 / 5872

页数：3

相关论文

共 24 条

[1] Role of the gerI operon of Bacillus cereus 569 in the response of spores to germinants [J].

Clements, MO ;

Moir, A .

JOURNAL OF BACTERIOLOGY, 1998, 180 (24) :6729-6735

[2] Anthrax [J].

Dixon, TC ;

Meselson, M ;

Guillemin, J ;

Hanna, PC .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (11) :815-826

[3] Early Bacillus anthracis macrophage interactions:: intracellular survival and escape [J].

Dixon, TC ;

Fadl, AA ;

Koehler, TM ;

Swanson, JA ;

Hanna, PC .

CELLULAR MICROBIOLOGY, 2000, 2 (06) :453-463

[4] GENTAMICIN KILLS INTRACELLULAR LISTERIA-MONOCYTOGENES [J].

DREVETS, DA ;

CANONO, BP ;

LEENEN, PJM ;

CAMPBELL, PA .

INFECTION AND IMMUNITY, 1994, 62 (06) :2222-2228

[5] PULLING THE TRIGGER - THE MECHANISM OF BACTERIAL SPORE GERMINATION [J].

FOSTER, SJ ;

JOHNSTONE, K .

MOLECULAR MICROBIOLOGY, 1990, 4 (01) :137-141

[6] Antibiotic-resistance cassettes for Bacillus subtilis [J].

GueroutFleury, AM ;

Shazand, K ;

Frandsen, N ;

Stragier, P .

GENE, 1995, 167 (1-2) :335-336

[7] Germination of Bacillus anthracis spores within alveolar macrophages [J].

Guidi-Rontani, C ;

Weber-Levy, M ;

Labruyère, E ;

Mock, M .

MOLECULAR MICROBIOLOGY, 1999, 31 (01) :9-17

[8] Identification and characterization of a germination operon on the virulence plasmid pXOI of Bacillus anthracis [J].

Guidi-Rontani, C ;

Pereira, Y ;

Ruffie, S ;

Sirard, JC ;

Weber-Levy, M ;

Mock, M .

MOLECULAR MICROBIOLOGY, 1999, 33 (02) :407-414

[9] Fate of germinated Bacillus anthracis spores in primary murine macrophages [J].

Guidi-Rontani, C ;

Levy, M ;

Ohayon, H ;

Mock, M .

MOLECULAR MICROBIOLOGY, 2001, 42 (04) :931-938

[10] GERMINATION OF B ANTHRACIS SPORES IN PERITONEAL CAVITY OF RATS AND ESTABLISHMENT OF ANTHRAX [J].

HACHISUKA, Y .

JAPANESE JOURNAL OF MICROBIOLOGY, 1969, 13 (02) :199-+