Synthesis and cytotoxic activity of novel quinazolino-β-carboline-5-one derivatives

被引：48

作者：

Baruah, B

Dasu, K

Valtilingam, B

Mamnoor, P

Venkata, PP

Rajagopal, S

Yeleswarapu, KR

机构：

[1] Dr Reddys Labs Ltd, Discovery Res, Discovery Chem, Hyderabad 500050, Andhra Pradesh, India

[2] Dr Reddys Labs Ltd, Discovery Res, Mol Discovery, Hyderabad 500050, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 09期

关键词：

cytotoxic; quinazolino-beta-carboline-5-one derivatives;

D O I：

10.1016/j.bmc.2004.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel series of quinazolino-beta-carbolinone derivatives was synthesized and evaluated for their in vitro and in vivo anticancer activity. Many compounds have shown good in vitro activity in the range 1-8 muM concentration. Three of the compounds were further tested in nude mice bearing HT-29 colon cancer xenografts. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1991 / 1994

页数：4

共 17 条

[1] INTERNUCLEAR CYCLISATION .11. THE SYNTHESIS OF IND-N-METHYL-ALPHA-CARBOLINES [J].