Naive and Primed Pluripotent States

被引：1357

作者：

Nichols, Jennifer ^{[1
,2
]}

Smith, Austin ^{[1
,3
]}

机构：

[1] Univ Cambridge, Wellcome Trust Ctr Stem Cell Res, Cambridge CB2 1QR, England

[2] Univ Cambridge, Dept Psychiat Dev & Neurosci, Cambridge CB2 1QR, England

[3] Univ Cambridge, Dept Biochem, Cambridge CB2 1QR, England

来源：

CELL STEM CELL | 2009年 / 4卷 / 06期

基金：

英国医学研究理事会;

关键词：

EMBRYONIC STEM-CELLS; PRIMORDIAL GERM-CELLS; SELF-RENEWAL; TRANSCRIPTION FACTOR; PRIMITIVE ENDODERM; MOUSE EPIBLAST; GROUND-STATE; NANOG; EXPRESSION; DERIVATION;

D O I：

10.1016/j.stem.2009.05.015

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

After maternal predetermination gives way to zygotic regulation, a ground state is established within the mammalian embryo. This tabula rasa for embryogenesis is present only transiently in the preimplantation epiblast. Here, we consider how unrestricted cells are first generated and then prepared for lineage commitment. We propose that two phases of pluripotency can be defined: naive and primed. This distinction extends to pluripotent stem cells derived from embryos or by molecular reprogramming ex vivo.

引用

页码：487 / 492

页数：6

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