Genetic variation of the prevailing porcine respiratory and reproductive syndrome viruses occurring on a pig farm upon vaccination

被引：34

作者：

Kiss, I.

Sami, L.

Kecskemeti, S.

Hanada, K.

机构：

[1] Inst Debrecen, Cent Vet Inst, H-4031 Debrecen, Hungary

[2] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

来源：

ARCHIVES OF VIROLOGY | 2006年 / 151卷 / 11期

关键词：

D O I：

10.1007/s00705-006-0805-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recurrence of porcine respiratory and reproductive syndrome (PRRS) was observed on a pig farm after introducing two PRRS live virus vaccines to combat preceding outbreaks. The phylogenetic analysis of the nucleotide sequence encoding the GP5 envelope glycoprotein and the nucleocapsid protein coding sequences (ORF5 and ORF7, respectively) showed a close genetic relationship between the new outbreak-related and one of the vaccine viruses, while the prevailing PRRS virus genetic variants disappeared from the farm. These findings, supported by the epidemiological data, indicate that the new variant PRRS viruses might originate from a vaccine virus and demonstrate the limited efficacy of modified live vaccines against heterologous PRRS virus strains.

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页码：2269 / 2276

页数：8

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