Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles

被引：43

作者：

D'Angelo, Noel D.

Peterson, Joseph J.

Booker, Shon K.

Fellows, Ingrid

Dominguez, Celia

Hungate, Randall

Reider, Paul J.

Kim, Tae-Seong

机构：

[1] Amgen Inc, Dept Chem Res & Dev, Thousand Oaks, CA 91320 USA

[2] Rochester Inst Technol, Dept Chem, Rochester, NY 14623 USA

[3] Calif State Univ Fresno, Dept Chem, Fresno, CA 93740 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 29期

关键词：

Ullmann ether synthesis; microwave;

D O I：

10.1016/j.tetlet.2006.05.103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5045 / 5048

页数：4

共 35 条

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