Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration

被引：30

作者：

Hebrok, M ^{[1
]}

Reichardt, LF

机构：

[1] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 04期

关键词：

D O I：

10.1016/j.tcb.2004.02.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A recent publication shows that two integrins, alpha6beta4 and alpha3beta1, interact with netrin-1, a protein best known for its role in axon guidance. Consistent with a role in pancreatic development in vivo, netrin is expressed together with these integrins in fetal pancreatic epithelium. The paper presents strong evidence that pancreatic epithelial cells adhere, spread and migrate on netrin-coated substrata through alpha6beta4. Data also indicate that 0,01 mediates HGF-stimulated cell migration on netrin-coated substrata. These results indicate that netrins might have much broader functions than previously suspected.

引用

页码：153 / 155

页数：3

共 27 条

[1] The CCN family: a new stimulus package [J].

Brigstock, DR .

JOURNAL OF ENDOCRINOLOGY, 2003, 178 (02) :169-175

[2] A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons [J].

Butler, SJ ;

Dodd, J .

NEURON, 2003, 38 (03) :389-401

[3] The morphogen Sonic hedgehog is an axonal chemoattractant that collaborates with Netrin-1 in midline axon guidance [J].

Charron, F ;

Stein, E ;

Jeong, J ;

McMahon, AP ;

Tessier-Lavigne, M .

CELL, 2003, 113 (01) :11-23

[4] Expression and function of αvβ3 and αvβ5 integrins in the developing pancreas:: Roles in the adhesion and migration of putative endocrine progenitor cells [J].

Cirulli, V ;

Beattie, GM ;

Klier, G ;

Ellisman, M ;

Ricordi, C ;

Quaranta, V ;

Frasier, F ;

Ishii, JK ;

Hayek, A ;

Salomon, DR .

JOURNAL OF CELL BIOLOGY, 2000, 150 (06) :1445-1459

[5] Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells [J].

De Breuck, S ;

Lardon, J ;

Rooman, I ;

Bouwens, L .

DIABETOLOGIA, 2003, 46 (07) :926-933

[6]

GIANBRECHT BV, 2003, J BIOL CHEM, V278, P32561

[7] THE UNC-5, UNC-6, AND UNC-40 GENES GUIDE CIRCUMFERENTIAL MIGRATIONS OF PIONEER AXONS AND MESODERMAL CELLS ON THE EPIDERMIS IN C-ELEGANS [J].

HEDGECOCK, EM ;

CULOTTI, JG ;

HALL, DH .

NEURON, 1990, 4 (01) :61-85

[8] Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1 [J].

Höpker, VH ;

Shewan, D ;

Tessier-Lavigne, M ;

Poo, MM ;

Holt, C .

NATURE, 1999, 401 (6748) :69-73

[9] Signaling at the growth cone: Ligand-receptor complexes and the control of axon growth and guidance [J].

Huber, AB ;

Kolodkin, AL ;

Ginty, DD ;

Cloutier, JF .

ANNUAL REVIEW OF NEUROSCIENCE, 2003, 26 :509-563

[10] Integrins: Bidirectional, allosteric signaling machines [J].

Hynes, RO .

CELL, 2002, 110 (06) :673-687

← 1 2 3 →