Ventilator-induced lung injury: in vivo and in vitro mechanisms

被引：88

作者：

Matthay, MA

Bhattacharya, S

Gaver, D

Ware, LB

Lim, LHK

Syrkina, O

Eyal, F

Hubmayr, R

机构：

[1] Univ Calif San Francisco, Inst Cardiovasc Res, Dept Med, San Francisco, CA 94115 USA

[2] Univ Calif San Francisco, Inst Cardiovasc Res, Dept Anesthesia, San Francisco, CA 94115 USA

[3] Columbia Univ, Lung Biol Lab, New York, NY 10019 USA

[4] Tulane Univ, Dept Biomed Engn, New Orleans, LA 70118 USA

[5] Vanderbilt Univ, Dept Pulm & Crit Care Med, Nashville, TN 37232 USA

[6] Johns Hopkins Asthma & Allergy Ctr, Baltimore, MD 21224 USA

[7] Massachusetts Gen Hosp, Dept Pulm & Crit Care Med, Boston, MA 02114 USA

[8] Univ S Alabama, Dept Pediat, Mobile, AL 36604 USA

[9] Mayo Clin & Mayo Fdn, Div Pulm & Crit Care, Rochester, MN 55905 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2002年 / 283卷 / 04期

关键词：

acute lung injury; macrophages; neutrophils;

D O I：

10.1152/ajplung.00154.2002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.

引用

页码：L678 / L682

页数：5

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