Self Assembling and Crosslinking of Polyelectrolyte Multilayer Films of Chitosan and Alginate Studied by QCM and IR Spectroscopy

被引：109

作者：

Alves, Natalia M. ^{[1
,2
]}

Picart, Catherine ^{[3
,4
]}

Mano, Joao F. ^{[1
,2
]}

机构：

[1] Univ Minho, Dept Polymer Engn, Res Grp Biomat Biodegradables & Biomimet, P-4806909 Caldas Das Taipas, Guimaraes, Portugal

[2] IBB, Braga, Portugal

[3] Univ Montpellier 2, CNRS, F-34095 Montpellier, France

[4] Univ Montpellier I, CNRS, F-34095 Montpellier, France

来源：

MACROMOLECULAR BIOSCIENCE | 2009年 / 9卷 / 08期

关键词：

chitosan; crosslinking; films; layer growth; polyelectrolytes; viscoelastic properties; QUARTZ-CRYSTAL MICROBALANCE; CHONDROITIN SULFATE; SURFACE SCIENCE; CELL-ADHESION; POLYMER-FILMS; IN-VITRO; LAYER; HYDROGELS; MICROCAPSULES; DISSIPATION;

D O I：

10.1002/mabi.200800336

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The formation of novel biocompatible multilayer films based on the alternate deposition of CHI and ALG was investigated for the first time by QCM-D and FTIR-ATR. A linear increase of the thickness was found during the film build-up. GLUT was used to crosslink the films terminated with either CHI or ALG. A change in the QCM-D signal was observed just in the first case, indicating that crosslinking only takes place in the top CHI layer. The evolution of the dissipation factor during crosslinking was modelled with a first-order kinetics; this reaction was found to be faster for chitosan terminated films with a lower number of multilayers. It was also found that more robust films could be produced by crosslinking the intermediate CHI layers during the build-up.

引用

页码：776 / 785

页数：10

共 61 条

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