Epithelial-Mesenchymal Transition and Podocyte Loss in Diabetic Kidney Disease

被引:150
作者
Reidy, Kimberly [1 ]
Susztak, Katalin [1 ]
机构
[1] Albert Einstein Coll Med, Bronx, NY 10461 USA
关键词
INTEGRIN-LINKED KINASE; TGF-BETA; SLIT DIAPHRAGM; INJURY; NEPHROPATHY; EXPRESSION; APOPTOSIS; PATHWAY; BIOLOGY;
D O I
10.1053/j.ajkd.2009.07.003
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
100201 [内科学]; 100221 [泌尿外科学];
摘要
引用
收藏
页码:590 / 593
页数:4
相关论文
共 29 条
[1]
Transforming growth factor-β in renal disease [J].
Bitzer, M ;
Sterzel, RB ;
Böttinger, EP .
KIDNEY & BLOOD PRESSURE RESEARCH, 1998, 21 (01) :1-12
[2]
Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling [J].
Dai, Chunsun ;
Stolz, Donna B. ;
Bastacky, Sheldon I. ;
St Arnaud, Rene ;
Wu, Chuanyue ;
Dedhar, Shoukat ;
Liu, Youhua .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (08) :2164-2175
[3]
Nephrin expression is reduced in human diabetic nephropathy - Evidence for a distinct role for glycated albumin and angiotensin II [J].
Doublier, S ;
Salvidio, G ;
Lupia, E ;
Ruotsalainen, V ;
Verzola, D ;
Deferrari, G ;
Camussi, G .
DIABETES, 2003, 52 (04) :1023-1030
[4]
Podocyte injury and targeting therapy: an update [J].
Durvasula, RV ;
Shankland, SJ .
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2006, 15 (01) :1-7
[5]
Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis [J].
El-Aouni, Chiraz ;
Herbach, Nadja ;
Blattner, Simone M. ;
Henger, Anna ;
Rastaldi, Maria P. ;
Jarad, George ;
Miner, Jeffrey H. ;
Moeller, Marcus J. ;
St-Arnaud, Rene ;
Dedhar, Shoukat ;
Holzman, Lawrence B. ;
Wanke, Ruediger ;
Kretzler, Matthias .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (05) :1334-1344
[6]
An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms [J].
Hirose, Tomonori ;
Satoh, Daisuke ;
Kurihara, Hidetake ;
Kusaka, Chiho ;
Hirose, Hiroko ;
Akimoto, Kazunori ;
Matsusaka, Taiji ;
Ichikawa, Iekuni ;
Noda, Tetsuo ;
Ohno, Shigeo .
PLOS ONE, 2009, 4 (01)
[7]
Loss of Podocyte aPKCλ/ι Causes Polarity Defects and Nephrotic Syndrome [J].
Huber, Tobias B. ;
Hartleben, Bjoern ;
Winkelmann, Kirstin ;
Schneider, Lisa ;
Becker, Jan U. ;
Leitges, Michael ;
Walz, Gerd ;
Haller, Hermann ;
Schiffer, Mario .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (04) :798-806
[8]
Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat [J].
Kim, YH ;
Goyal, M ;
Kurnit, D ;
Wharram, B ;
Wiggins, J ;
Holzman, L ;
Kershaw, D ;
Wiggins, R .
KIDNEY INTERNATIONAL, 2001, 60 (03) :957-968
[9]
Advanced glycation end products activate Smad signaling via TGF-β-dependent and -independent mechanisms: implications for diabetic renal and vascular disease [J].
Li, JH ;
Huang, XR ;
Zhu, HJ ;
Oldfield, M ;
Cooper, M ;
Truong, LD ;
Johnson, RJ ;
Lan, HY .
FASEB JOURNAL, 2004, 18 (01) :176-178
[10]
Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria [J].
Li, Yingjian ;
Kang, Young Sun ;
Dai, Chunsun ;
Kiss, Lawrence P. ;
Wen, Xiaoyan ;
Liu, Youhua .
AMERICAN JOURNAL OF PATHOLOGY, 2008, 172 (02) :299-308