Identification of new catalysts for the asymmetric reduction of imines into chiral amines with polymethylhydrosiloxane using high-throughput screening

被引：27

作者：

Ireland, T ^{[1
]}

Fontanet, F ^{[1
]}

Tchao, GG ^{[1
]}

机构：

[1] Rhodia, Lyon Res Ctr, Catalysis Dept, F-69192 St Fons, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 22期

关键词：

asymmetric imine reduction; PMHS; high-throughput screening;

D O I：

10.1016/j.tetlet.2004.03.159

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of high-throughput techniques allowed the rapid identification of new catalysts for the enantioselective reduction of imines using polymethylhydrosiloxane (PMHS) as a reducing agent. By a simple modification of the chiral ligand structure that came out of the screening, the enantioselectivity of the reduction was increased from 40% ee to 60% ec. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4383 / 4387

页数：5

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