Synthesis and biological evaluation of α, β-unsaturated ketone as potential antifungal agents

被引：52

作者：

Bag, Seema ^{[1
]}

Ramar, S. ^{[1
]}

Degani, Mariam S. ^{[1
]}

机构：

[1] Univ Inst Chem Technol, Dept Pharmaceut Sci & Technol, Bombay 400019, Maharashtra, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2009年 / 18卷 / 04期

关键词：

alpha; beta-unsaturated ketone (chalcones); Antifungal agents; Fluconazole resistant; ANTIMICROBIAL EVALUATION; INHIBITORY PROPERTIES; ANTICANDIDA ACTIVITY; CHALCONES; DERIVATIVES; GROWTH;

D O I：

10.1007/s00044-008-9128-x

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

With the aim of developing potential antifungals, a series of chalcones incorporating sulfur either as part of a heteroaromatic ring (thiophene) or as a side chain (thiomethyl group) were synthesized and tested for their in vitro activity. Some of the compounds showed appreciable activity against a fluconazole-resistant strain, and could act as new hits for the design of better analogs.

引用

页码：309 / 316

页数：8

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