Effects of insulin-like growth factor-I and LR(3)IGF-I on regional blood flow in normal rats

被引:36
作者
Gillespie, CM
Merkel, AL
Martin, AA
机构
[1] Coop. Res. Ctr. Tissue Growth Repair, Child Health Research Institute, North Adelaide
[2] Child Health Research Institute, North Adelaide, SA 5006
关键词
D O I
10.1677/joe.0.1550351
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Two studies were conducted to investigate the haemodynamic effects of IGF-I and its analogue LR(3)IGF-I in normal anaesthetised rats. Infusion of IGF-I intravenously, at a dose of 125 mu g/kg/h, for 20 min in the first study resulted in renal blood flow being significantly elevated by 35% above baseline. Mean arterial blood pressure (MABP) at this IGF-I dose fell by 18% of baseline, with LR(3)IGF-I also causing a significant decline in MABP (by 15%) at the dose of 125 mu g/kg/h. In the second study the intravenous administration of IGF-I or LR(3)IGF-I, at a dose of 125 mu g/kg/h, over a period of 60 min, resulted in MABP being significantly lowered by 25% of baseline values. Regional blood flow rates were determined using radioactive microspheres, 15 mu m in diameter, injected systemically at the end of the peptide infusion period. The gastrocnemius, a representative skeletal muscle, was the only vascular region to shaw a significant increase in blood flow after IGF-I (by 58%) or LR(3)IGF-I (by 308%) infusion. Vascular resistance in the brain was significantly reduced after infusion of IGF-I (by 60%) or LR(3)IGF-I (by 48%) as compared with vehicle. Skeletal muscle vascular resistance was also reduced by IGF-I (by 41%) and more particularly by LR(3)IGF-I (by 77%) in comparison to vehicle. These alterations to vascular tone produced by IGF infusion may be related to the central nervous system and systemic cardiovascular side-effects that have been reported during IGF-I administration in humans.
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页码:351 / 358
页数:8
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