Effect of vitamin E on lipid peroxidation and liver monooxygenase activity in experimental influenza virus infection

被引：28

作者：

Mileva, M

Tacheva, L

Bakalova, R

Galabov, A

Savov, V

Ribarov, S

机构：

[1] Med Univ Sofia, Dept Med Phys & Biophys, Sofia 1431, Bulgaria

[2] Bulgarian Acad Sci, Inst Physiol, BU-1113 Sofia, Bulgaria

[3] Bulgarian Acad Sci, Inst Microbiol, BU-1113 Sofia, Bulgaria

来源：

TOXICOLOGY LETTERS | 2000年 / 114卷 / 1-3期

关键词：

lipid peroxidation; liver monooxygenases; vitamin E; influenza virus infection;

D O I：

10.1016/S0378-4274(99)00265-9

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADPH-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：39 / 45

页数：7

共 17 条

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