Highly stereoselective synthesis of steroidal 2,5-diketopiperazines based on isocyanide chemistry

被引：22

作者：

Bruttomesso, Andrea C. ^{[1
]}

Eiras, Javier

Ramirez, Javier A.

Galagovsky, Lydia R.

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, CONICET, RA-1428 Buenos Aires, DF, Argentina

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 28期

关键词：

2,5-Diketopiperazines; Heterocyclic steroids; Multicomponent reaction; Ugi reaction; CYP17; INHIBITORS; DERIVATIVES;

D O I：

10.1016/j.tetlet.2009.03.219

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

In this Letter we report that the Ugi reaction/cyclization sequence on a steroidal 17-carboxaldehyde leads to novel steroidal 2,5-diketopiperazines with a noteworthy stereoselectivity. A wide variety in the substitution pattern in the heterocyclic moiety was easily achieved by changing the components in the Ugi reaction. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4022 / 4024

页数：3

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