Immunomodulatory agents for prophylaxis and therapy of infections

被引：52

作者：

Masihi, KN ^{[1
]}

机构：

[1] Robert Koch Inst, D-13353 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2000年 / 14卷 / 03期

关键词：

immunomodulators; cytokines; infectious diseases;

D O I：

10.1016/S0924-8579(99)00161-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The advent of the antibiotic era ushered in a shift towards non-pathogen-specific therapy of infectious diseases. This led to an overt emphasis on targeting microbial pathogens while strategies directed towards enhancing host immunity were neglected. In an effort to decrease sole reliance on antimicrobials, the time has come for a critical reappraisal of nonantibiotic, albeit immune response-enhancing substances. The diverse array of natural, synthetic, and recombinant immunomodulators discussed in this review succinctly demonstrate the potential of these agents to stimulate host defense mechanisms for prophylaxis and treatment of various microbial infections. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

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页码：181 / 191

页数：11

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