Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom

被引：217

作者：

Conde, R

Zamudio, FZ

Rodríguez, MH

Possani, LD

机构：

[1] Univ Nacl Autonoma Mexico, Inst Biotechnol, Dept Mol Recognit & Struct Biol, Cuernavaca 62210, Morelos, Mexico

[2] Natl Inst Publ Hlth, Ctr Invest Enfermedades Infecciosas, Cuernavaca 62508, Morelos, Mexico

来源：

FEBS LETTERS | 2000年 / 471卷 / 2-3期

关键词：

antibiotic; malaria; scorpine; Pandinus imperator; Plasmodium;

D O I：

10.1016/S0014-5793(00)01384-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel peptide, scorpine, was isolated from the venom of the scorpion Pandinus imperator, with anti-bacterial activity and a potent inhibitory effect on the ookinete (ED50 0.7 mu M) and gamete (ED50 10 mu M) stages of Plasmodium berghei development. It has 75 amino acids, three disulfide bridges with a molecular mass of 8350 Da. Scorpine has a unique amino acid sequence, similar only to some cecropins in its N-terminal segment and to some defensins in its C-terminal region, its gene was cloned from a cDNA library. (C) 2000 Federation of European Biochemical Societies.

引用

页码：165 / 168

页数：4

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