The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study

被引：135

作者：

Papaioannou, A. ^{[1
]}

Kennedy, C. C. ^{[1
]}

Ioannidis, G. ^{[1
,2
]}

Sawka, A. ^{[3
]}

Hopman, W. M. ^{[4
]}

Pickard, L. ^{[1
,2
]}

Brown, J. P. ^{[5
]}

Josse, R. G. ^{[3
]}

Kaiser, S. ^{[6
]}

Anastassiades, T. ^{[4
]}

Goltzman, D. ^{[7
]}

Papadimitropoulos, M. ^{[3
,8
]}

Tenenhouse, A. ^{[7
]}

Prior, J. C. ^{[9
]}

Olszynski, W. P. ^{[10
]}

Adachi, J. D. ^{[1
,2
]}

机构：

[1] McMaster Univ, Hamilton, ON L8N 3Z5, Canada

[2] St Josephs Hosp, Hamilton, ON, Canada

[3] Univ Toronto, Toronto, ON, Canada

[4] Queens Univ, Kingston, ON, Canada

[5] Univ Laval, Ste Foy, PQ G1K 7P4, Canada

[6] Dalhousie Univ, Halifax, ON, Canada

[7] McGill Univ, Montreal, PQ, Canada

[8] Eli Lilly & Co, Toronto, ON, Canada

[9] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[10] Univ Saskatchewan, Saskatoon, SK, Canada

来源：

OSTEOPOROSIS INTERNATIONAL | 2009年 / 20卷 / 05期

基金：

加拿大健康研究院;

关键词：

Cost-utility; Epidemiology; Fractures; Health utilities index; Osteoporosis; Quality of life; UTILITIES INDEX; VERTEBRAL FRACTURES; HIP FRACTURE; WOMEN; CAMOS; MORTALITY; CONSEQUENCES; ASSOCIATION; SYSTEM; CANCER;

D O I：

10.1007/s00198-008-0743-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using prospective data from the Canadian Multicentre Osteoporosis Study (CaMos), we compared health utilities index (HUI) scores after 5 years of follow-up among participants (50 years and older) with and without incident clinical fractures. Incident fractures had a negative impact on HUI scores over time. This study examined change in health-related quality of life (HRQL) in those with and without incident clinical fractures as measured by the HUI. The study cohort was 4,820 women and 1,783 men (50 years and older) from the CaMos. The HUI was administered at baseline and year 5. Participants were sub-divided into incident fracture groups (hip, rib, spine, forearm, pelvis, other) and were compared with those without these fractures. The effects of both time and fracture type on HUI scores were examined in multivariable regression analyses. Men and women with hip fractures, compared to those without, had lower HUI measures that ranged from -0.05 to -0.25. Both women and men with spine fractures had significant deficits on the pain attributes (-0.07 to -0.12). In women, self-care (-0.06), mobility and ambulation (-0.05) were also negatively impacted. Women with rib fractures had deficits similar to women with spine fractures, and these effects persisted over time. In men, rib fractures did not significantly affect HUI scores. Pelvic and forearm fractures did not substantially influence HUI scores. The HUI was a sensitive measure of HRQL change over time. These results will inform economic analyses evaluating osteoporosis therapies.

引用

页码：703 / 714

页数：12

共 35 条

[1] The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos) [J].