Pattern recognition receptors: A contemporary view on liver diseases

被引：142

作者：

Szabo, Gyongyi ^{[1
]}

Dolganiuc, Angela ^{[1
]}

Mandrekar, Pranoti ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Div Gastroenterol,Liver Ctr, Worcester, MA 01605 USA

来源：

HEPATOLOGY | 2006年 / 44卷 / 02期

关键词：

D O I：

10.1002/hep.21308

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver. This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated.

引用

页码：287 / 298

页数：12

共 176 条

[91] Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus [J].