Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

被引：554

作者：

Pan, Y

Lloyd, C

Zhou, H

Dolich, S

Deeds, J

Gonzalo, JA

Vath, J

Gosselin, M

Ma, JY

Dussault, B

Woolf, E

Alperin, G

Culpepper, J

GutierrezRamos, JC

Gearing, D

机构：

[1] Millennium Pharmaceuticals Inc., Cambridge, MA 02139

来源：

NATURE | 1997年 / 387卷 / 6633期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/42491

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chemokines are small secreted proteins that stimulate the directional migration of leukocytes and mediate inflammation(1-4). During screening of a murine choroid plexus complementary DNA library, we identified a new chemokine, designated neurotactin. Unlike other chemokines, neurotactin has a unique cysteine pattern, Cys-X-X-X-Cys, and is predicted to be a type 1 membrane protein. Full-length recombinant neurotactin is localized on the surface of transfected 293 cells. Recombinant neurotactin containing the chemokine domain is chemotactic for neutrophils both in vitro and in vivo. Neurotactin messenger RNA is predominantly expressed in normal murine brain and its protein expression in activated brain microglia is upregulated in mice with experimental autoimmune encephalomyelitis, as well as in mice treated with lipopolysaccharide. Distinct from all other chemokine genes, the neurotactin gene is localized to human chromosome 16q. Consequently we propose that neurotactin represents a new delta-chemokine family and that it may play a role in brain inflammation processes.

引用

页码：611 / 617

页数：7

共 31 条

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