Antiestrogenic compounds inhibit estrogen-induced expressions of basic fibroblast growth factor and its mRNA in well-differentiated endometrial cancer cells

被引：23

作者：

Fujimoto, J

Hori, M

Ichigo, S

Hirose, R

Tamaya, T

机构：

[1] Dept. of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City 500

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1997年 / 28卷 / 02期

关键词：

basic FGF; mRNA; endometrial cancer (Ishikawa) cell line; antiestrogen compounds;

D O I：

10.1016/S0306-3623(96)00188-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The levels of basic fibroblast growth factor (FGF) expression and secretion and its messenger ribonucleic acid (mRNA) expression in well-differentiated endometrial cancer (Ishikawa) cells were significantly increased by estradiol. 2. This increase was significantly inhibited by tamoxifen, progestins (progesterone, medroxyprogesterone acetate [MPA], and 17 alpha-hydroxyprogesterone), and to some extent danazol, but not by terahydrocortisol and hydrocortisone. 3. Estrogen might stimulate the basic FGF secretion of endometrial cancer cells, at least for neovascularization, and antiestrogenic compounds may inhibit the estrogen-induced event. Copyright (C) 1997 Elsevier Science Inc.

引用

页码：215 / 219

页数：5