Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer

被引：129

作者：

Cao, Yue ^{[1
]}

Gang, Xiaokun ^{[1
]}

Sun, Chenglin ^{[1
]}

Wang, Guixia ^{[1
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Endocrinol & Metab, Changchun 130021, Peoples R China

来源：

JOURNAL OF DIABETES RESEARCH | 2017年 / 2017卷

关键词：

UMBILICAL-CORD BLOOD; HUMAN BONE-MARROW; LIMBAL EPITHELIAL TRANSPLANTATION; STROMAL CELLS; ADIPOSE-TISSUE; MULTILINEAGE DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; CONDITIONED MEDIUM; GROWTH-FACTOR; THERAPY;

D O I：

10.1155/2017/9328347

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Mesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has demonstrated that MSCs transplantation can accelerate wound closure, ameliorate clinical parameters, and avoid amputation. In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation.

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页数：10

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