Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: A review

被引:108
作者
Hector, Suzanne [1 ,2 ]
Prehn, Jochen H. M. [1 ,2 ]
机构
[1] Royal Coll Surgeons Ireland, Ctr Human Prote, Dublin 2, Ireland
[2] Royal Coll Surgeons Ireland, Dept Physiol & Med Phys, Dublin 2, Ireland
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2009年 / 1795卷 / 02期
关键词
Colorectal cancer; Apoptosis; Biomarker; Prognosis; BCL-2; FAMILY-MEMBER; CELL GROWTH-FACTOR; COLON-CANCER; STAGE-II; ADJUVANT CHEMOTHERAPY; MISMATCH REPAIR; GENE-EXPRESSION; MESSENGER-RNA; CYTOCHROME-C; FAS LIGAND;
D O I
10.1016/j.bbcan.2008.12.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Colorectal cancer is a leading cause of cancer related mortality in the Western world. In recent years, combination 5-fluorouracil based adjuvant chemotherapy as first line treatment of this disease has led to improved disease free and overall survival. However drug resistance, both innate and acquired, remains an obstacle in the effective treatment of this disease. Apoptotic pathways are frequently altered in both tumor progression and drug resistance; therefore proteins associated with this pathway may have potential as prognostic biomarkers for this disease. Identification of clinical biomarkers that are able to identify patients who are more likely to respond to specific chemotherapy will lead to more personalized, effective, and less toxic therapy. This review focuses on the current status of apoptosis related proteins as biomarkers for colorectal cancer and discusses the possible application of systems approaches in this context. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:117 / 129
页数:13
相关论文
共 184 条
[1]   Role of BAX mutations in mismatch repair-deficient colorectal carcinogenesis [J].
Abdel-Rahman, WM ;
Georgiades, IB ;
Curtis, LJ ;
Arends, MJ ;
Wyllie, AH .
ONCOGENE, 1999, 18 (12) :2139-2142
[2]   Death pathway genes Fas (Apo-1/CD95) and Bik (Nbk) show no mutations in colorectal carcinomas [J].
Abdel-Rahman, WM ;
Arends, MJ ;
Wyllie, AH ;
Morris, RG ;
Ramadan, ME .
CELL DEATH AND DIFFERENTIATION, 1999, 6 (05) :387-388
[3]   Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers [J].
Ahn, Chang Hyeok ;
Jeong, Eun Goo ;
Lee, Jong Woo ;
Kim, Min Sung ;
Kim, Sung Hee ;
Kim, Sung Soo ;
Yoo, Nam Jin ;
Lee, Sug Hyung .
APMIS, 2007, 115 (12) :1344-1349
[4]   Quantitative analysis of pathways controlling extrinsic apoptosis in single cells [J].
Albeck, John G. ;
Burke, John M. ;
Aldridge, Bree B. ;
Zhang, Mingsheng ;
Lauffenburger, Douglas A. ;
Sorger, Peter K. .
MOLECULAR CELL, 2008, 30 (01) :11-25
[5]   Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].
Alizadeh, AA ;
Eisen, MB ;
Davis, RE ;
Ma, C ;
Lossos, IS ;
Rosenwald, A ;
Boldrick, JG ;
Sabet, H ;
Tran, T ;
Yu, X ;
Powell, JI ;
Yang, LM ;
Marti, GE ;
Moore, T ;
Hudson, J ;
Lu, LS ;
Lewis, DB ;
Tibshirani, R ;
Sherlock, G ;
Chan, WC ;
Greiner, TC ;
Weisenburger, DD ;
Armitage, JO ;
Warnke, R ;
Levy, R ;
Wilson, W ;
Grever, MR ;
Byrd, JC ;
Botstein, D ;
Brown, PO ;
Staudt, LM .
NATURE, 2000, 403 (6769) :503-511
[6]   The case for survivin as a regulator of microtubule dynamics and cell-death decisions [J].
Altieri, Dario C. .
CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (06) :609-615
[7]   A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J].
Ambrosini, G ;
Adida, C ;
Altieri, DC .
NATURE MEDICINE, 1997, 3 (08) :917-921
[8]   Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor [J].
An, J. ;
Chervin, A. S. ;
Nie, A. ;
Ducoff, H. S. ;
Huang, Z. .
ONCOGENE, 2007, 26 (05) :652-661
[9]   Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer [J].
Andre, T ;
Boni, C ;
Mounedji-Boudiaf, L ;
Navarro, M ;
Tabernero, J ;
Hickish, T ;
Topham, C ;
Zaninelli, M ;
Clingan, P ;
Bridgewater, J ;
Tabah-Fisch, I ;
de Gramont, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (23) :2343-2351
[10]  
ASHKENAZI A, CYTOKINE GR IN PRESS