Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: A review

被引:108
作者
Hector, Suzanne [1 ,2 ]
Prehn, Jochen H. M. [1 ,2 ]
机构
[1] Royal Coll Surgeons Ireland, Ctr Human Prote, Dublin 2, Ireland
[2] Royal Coll Surgeons Ireland, Dept Physiol & Med Phys, Dublin 2, Ireland
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2009年 / 1795卷 / 02期
关键词
Colorectal cancer; Apoptosis; Biomarker; Prognosis; BCL-2; FAMILY-MEMBER; CELL GROWTH-FACTOR; COLON-CANCER; STAGE-II; ADJUVANT CHEMOTHERAPY; MISMATCH REPAIR; GENE-EXPRESSION; MESSENGER-RNA; CYTOCHROME-C; FAS LIGAND;
D O I
10.1016/j.bbcan.2008.12.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Colorectal cancer is a leading cause of cancer related mortality in the Western world. In recent years, combination 5-fluorouracil based adjuvant chemotherapy as first line treatment of this disease has led to improved disease free and overall survival. However drug resistance, both innate and acquired, remains an obstacle in the effective treatment of this disease. Apoptotic pathways are frequently altered in both tumor progression and drug resistance; therefore proteins associated with this pathway may have potential as prognostic biomarkers for this disease. Identification of clinical biomarkers that are able to identify patients who are more likely to respond to specific chemotherapy will lead to more personalized, effective, and less toxic therapy. This review focuses on the current status of apoptosis related proteins as biomarkers for colorectal cancer and discusses the possible application of systems approaches in this context. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:117 / 129
页数:13
相关论文
共 184 条
[31]   Bcl-2 and p53 protein expression, apoptosis, and p53 mutation in human epithelial ovarian cancers [J].
Chan, WY ;
Cheung, KK ;
Schorge, JO ;
Huang, LW ;
Welch, WR ;
Bell, DA ;
Berkowitz, RS ;
Mok, SC .
AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (02) :409-417
[32]  
Contu Paulo C., 2006, Arq. Gastroenterol., V43, P284, DOI 10.1590/S0004-28032006000400008
[33]   Phenotypic characterization of human colorectal cancer stem cells [J].
Dalerba, Piero ;
Dylla, Scott J. ;
Park, In-Kyung ;
Liu, Rui ;
Wang, Xinhao ;
Cho, Robert W. ;
Hoey, Timothy ;
Gurney, Austin ;
Huang, Emina H. ;
Simeone, Diane M. ;
Shelton, Andrew A. ;
Parmiani, Giorgio ;
Castelli, Chiara ;
Clarke, Michael F. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (24) :10158-10163
[34]   Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery [J].
Datta, SR ;
Dudek, H ;
Tao, X ;
Masters, S ;
Fu, HA ;
Gotoh, Y ;
Greenberg, ME .
CELL, 1997, 91 (02) :231-241
[35]   Tumour stem cells and drug resistance [J].
Dean, M ;
Fojo, T ;
Bates, S .
NATURE REVIEWS CANCER, 2005, 5 (04) :275-284
[36]   X-linked IAP is a direct inhibitor of cell-death proteases [J].
Deveraux, QL ;
Takahashi, R ;
Salvesen, GS ;
Reed, JC .
NATURE, 1997, 388 (6639) :300-304
[37]   NOXA and PUMA expression add to clinical markers in predicting biochemical recurrence of prostate cancer patients in a survival tree model [J].
Diallo, Jean-Simon ;
Aldejmah, Abdulhadi ;
Mouhim, Abdelali Filali ;
Peant, Benjamin ;
Fahmy, Mona Alam ;
Koumakpayi, Ismaeel Herve ;
Sircar, Kanishka ;
Begin, Louis R. ;
Mes-Masson, Anne-Marie ;
Saad, Fred .
CLINICAL CANCER RESEARCH, 2007, 13 (23) :7044-7052
[38]  
DiPaola RS, 1999, SEMIN ONCOL, V26, P24
[39]   Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis [J].
Dohi, T ;
Beltrami, E ;
Wall, NR ;
Plescia, J ;
Altieri, DC .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (08) :1117-1127
[40]   Concordance among gene-expression-based predictors for breast cancer [J].
Fan, Cheng ;
Oh, Daniel S. ;
Wessels, Lodewyk ;
Weigelt, Britta ;
Nuyten, Dimitry S. A. ;
Nobel, Andrew B. ;
van't Veer, Laura J. ;
Perou, Charles M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (06) :560-569