Chiral PEPPSI Complexes: Synthesis, Characterization, and Application in Asymmetric Suzuki-Miyaura Coupling Reactions

被引：105

作者：

Benhamou, Laure ^{[1
]}

Besnard, Celine ^{[1
]}

Kuendig, E. Peter ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

ORGANOMETALLICS | 2014年 / 33卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

HETEROCYCLIC CARBENE LIGANDS; ORTHO-SUBSTITUTED BIARYLS; PALLADIUM COMPLEXES; ENANTIOSELECTIVE SYNTHESIS; ARYL CHLORIDES; NHC; CATALYSTS; PRECATALYST; HYDRAZONES; INDOLINES;

D O I：

10.1021/om4009982

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

PEPPSI complexes incorporating chiral N-heterocyclic carbene (NHC) ligands based on 2,2-dimethyl-1-(o-substituted aryl)-propan-1-amines were synthesized. Two complexes, with one saturated and one unsaturated NHC ligand, were structurally characterized. The chiral PEPPSI complexes were used in asymmetric Suzuki-Miyaura reactions, giving atropisomeric biaryl products in modest to good enantiomeric ratios.

引用

页码：260 / 266

页数：7

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