FISH-mapped CEPH YACs spanning 0 to 46 cM on human chromosome 6

被引：12

作者：

BrayWard, P

Bowlus, C

Choi, BJ

LePaslier, D

Weissenbach, J

Gruen, JR

机构：

[1] YALE UNIV,SCH MED,DEPT INTERNAL MED,NEW HAVEN,CT 06510

[2] YALE UNIV,SCH MED,DEPT PEDIAT,NEW HAVEN,CT 06510

[3] CEPH GENETHON,F-91002 EVRY,FRANCE

来源：

GENOMICS | 1996年 / 36卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0430

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Seventy-six CEPH YACs were mapped by fluorescence in situ hybridization (FISH) to human metaphase chromosomes. These clones have been ordered from pter to 46 cM by combining the results of FISH with sequence-tagged site content mapping using data from the public databases. This created a minimal tiling path containing at least 37 Mb of human genomic DNA from 0 to 46 cM on chromosome 6 that contains up to four gaps not greater than 200 kb. These data provide an integration of the FLpter physical map values with cytogenetic band localization and markers on the genetic and radiation hybrid maps. We also assessed YAC chimerism and placed three additional Whitehead contigs (WC952, WC799, WC436) within the integrated map. (C) 1996 Academic Press, Inc.

引用

页码：104 / 111

页数：8

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