Dynamics of biological molecules irradiated by short x-ray pulses

被引：158

作者：

Hau-Riege, SP ^{[1
]}

London, RA ^{[1
]}

Szoke, A ^{[1
]}

机构：

[1] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA

来源：

PHYSICAL REVIEW E | 2004年 / 69卷 / 05期

关键词：

D O I：

10.1103/PhysRevE.69.051906

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

Very short and intense x-ray pulses can be used for diffraction imaging of single biological molecules. Inevitably, x-ray absorption initiates damage that degrades the molecule's image. This paper presents a continuum model of the physics that leads to damage when a small particle absorbs a large x-ray dose. The main processes are found to be ionization and Coulomb-force driven atomic motion. Trapping of electrons, Debye shielding, and nonuniform collisional ionization all have a significant effect on the overall damage kinetics.

引用

页码：12 / 1

页数：12

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