Acute promyelocytic leukemia:: PML/RARα and the leukemic stem cell

被引：65

作者：

Puccetti, E ^{[1
]}

Ruthardt, M ^{[1
]}

机构：

[1] Univ Frankfurt, Med Klin 3, Hamatol Abt, Lab Expt Hamatol, D-6000 Frankfurt, Germany

来源：

LEUKEMIA | 2004年 / 18卷 / 07期

关键词：

acute promyelocytic leukemia (APL); acute myeloid leukemia (AML); PML/RAR alpha; PLZF/RAR alpha; leukemic stem cell;

D O I：

10.1038/sj.leu.2403367

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute promyelocytic leukemia (APL) is distinguished from other acute myeloid leukemias (AMLs) by cytogenetic, clinical, as well as biological characteristics. The hallmark of APL is the t(15; 17), which leads to the expression of the PML/RARalpha fusion protein. PML/RARalpha is the central leukemia-inducing lesion in APL and is directly targeted by all trans retinoic acid (t-RA) as well as by arsenic, both compounds able to induce complete remissions. This review focuses on potential stem cell involvement in APL outlining the knowledge about the APL-initiating stem cell and the influence of PML/RARalpha on the biology of the hematopoietic stem cell. Moreover, the importance of the blockage of t-RA signaling by the PML/RARalpha for the pathogenesis of APL is discussed, taking the relevance of the t-RA signaling pathway for the global hematopoiesis into account.

引用

页码：1169 / 1175

页数：7

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