Effect of novel selective non-peptide kinin B1 receptor antagonists on mouse pleurisy induced by carrageenan

被引:16
作者
Costa, Robson
Fernandes, Elizabeth S.
Menezes-De-Lima, Octavio, Jr.
Campos, Maria M.
Calixto, Jodo B.
机构
[1] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Pharmacol, BR-88049900 Florianopolis, SC, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul, Sch Dent, Porto Alegre, RS, Brazil
关键词
B-1; receptor; peptide antagonists; non-peptide antagonists; carrageenan; pleurisy; mice;
D O I
10.1016/j.peptides.2006.07.007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two novel selective non-peptide kinin B-1 receptor antagonists, the benzodiazepine antagonist and SSR240612, were evaluated in carrageenan-induced mouse pleurisy. The peptide 8715 (0.5 mg/kg, i.p.) and the non-peptide benzodiazepine (3 mg/kg, i.p.) antagonists significantly decreased cellular migration (predominantly neutrophils), without altering plasma exudation. SSR240612 (1 mg/kg, i.p.) diminished total cells and neutrophils, besides exudation. Oral administration of SSR240612 (10 mg/kg) also reduced total cell and neutrophil counts. Only the benzodiazepine antagonist inhibited the lung myeloperoxidase activity. No tested antagonist significantly altered the lung and pleural TNF alpha and IL-1 beta production. We provide interesting evidence on the anti-inflammatory in vivo effects of non-peptide B-1 receptor antagonists. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:2967 / 2975
页数:9
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