Detection of Breast Cancer Microcalcifications Using a Dual-modality SPECT/NIR Fluorescent Probe

被引：113

作者：

Bhushan, Kumar R. ^{[1
]}

Misra, Preeti ^{[1
]}

Liu, Fangbing ^{[1
]}

Mathur, Sanjeev ^{[1
]}

Lenkinski, Robert E. ^{[2
]}

Frangioni, John V. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 52期

关键词：

D O I：

10.1021/ja807099s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

引用

页码：17648 / +

页数：3

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