Triterpene Acids Isolated from Lagerstroemia speciosa Leaves as α-Glucosidase Inhibitors

被引：148

作者：

Hou, Wenli

Li, Yanfang

Zhang, Qiang

Wei, Xin

Peng, Aihua

Chen, Lijuan ^{[1
]}

Wei, Yuquan

机构：

[1] Sichuan Univ, State Key Lab Biotherapy, Sch Life Sci, Chengdu 610041, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 05期

基金：

中国国家自然科学基金;

关键词：

antidiabetic activity; corosolic acid; EtOAc extract; alpha-glucosidase inhibitors; Lagerstroemia speciosa leaves; ADIPOCYTE DIFFERENTIATION; GLYCEMIC CONTROL; ACARBOSE; EXTRACT; HYPERGLYCEMIA; TRANSPORT;

D O I：

10.1002/ptr.2661

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The potential antidiabetic activity of ethyl acetate extract of the leaves of Lagerstroemia speciosa (LSL) was investigated by alpha-amylase and alpha-glucosidase inhibition assay. Six pentacyclic triterpenes (oleanolic acid, arjunolic acid, asiatic acid, maslinic acid, corosolic acid and 23-hydroxyursolic acid) were isolated from LSL. Their structures were determined by spectroscopic analysis and their alpha-glycosidase and alpha-amylase inhibitory activities were investigated. They exhibited no or weak inhibitory activity against alpha-amylase and middle alpha-glucosidase inhibitory activities. Corosolic acid, which shows best bioactivity against alpha-glucosidase (IC50 = 3.53 mu g/mL), contributes most to the alpha-glucosidase inhibitory activity of EtOAc extract. The kinetics of inhibition of corosolic acid was also discussed. Results from this study might provide the scientific evidence for LSL for the treatment of diabetes in traditional medicine. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：614 / 618

页数：5

共 24 条

[1]

ASANO N, 2001, FEBS LETT, V501, P84

[2]

Baron AD, 1998, DIABETES RES CLIN PR, V40, pS51

[3] Protection from vascular risk in diabetic hypertension [J].