Sex, hormones and affective arousal circuitry dysfunction in schizophrenia

被引：60

作者：

Goldstein, Jill M.

机构：

[1] Harvard Univ, Sch Med, Dept Psychiat, Brigham & Womens Hosp,Dept Psychiat, Boston, MA 02120 USA

[2] Connors Ctr Womens Hlth & Gender Biol, Div Womens Hlth, Dept Med, Boston, MA 02120 USA

[3] Beth Israel Deaconess Med Ctr, Dept Psychiat, Publ Psychiat Div, Massachusetts Mental Hlth Ctr, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

HORMONES AND BEHAVIOR | 2006年 / 50卷 / 04期

关键词：

schizophrenia; HPA and HPG axes; emotion; affective brain circuitry; sex differences;

D O I：

10.1016/j.yhbeh.2006.06.029

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Women with schizophrenia express affective disturbances disproportionately more than men. Brain regions implicated in the affective arousal circuitry also regulate the hypothalamic-pituitary-adrenal and -gonadal systems, which are dysfunctional in schizophrenia. This review will argue that understanding the etiology of affective arousal deficits in schizophrenia is intimately connected with characterizing the role of neuroendocrine dysfunction and sex effects in schizophrenia. Further, the etiology of these neuroendocrine deficits begins during fetal development, during a period of time that coincides with the sexual differentiation of the brain and the vulnerability for schizophrenia. Studying the links between deficits in neuroendocrine systems and the affective arousal system in schizophrenia will provide clues to understanding the development of sex differences in schizophrenia and thereby its etiology. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：612 / 622

页数：11

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