Design and implementation of a highly selective minimal self-replicating system

被引：66

作者：

Kassianidis, Eleftherios

Philp, Douglas ^{[1
]}

机构：

[1] Univ St Andrews, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 38期

基金：

英国生物技术与生命科学研究理事会;

关键词：

kinetics; molecular modeling; self-replication; supramolecular chemistry; template synthesis;

D O I：

10.1002/anie.200601845

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Self-direction: A rationally designed self-complementary template (see picture) is capable of replication, thereby amplifying itself from a reaction mixture to the exclusion of its diastereomer. This approach allows a highly selective amplification by focusing on templates that display a high level of complementarity to transition states. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6344 / 6348

页数：5