Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission

被引：209

作者：

Chauvin, Alain ^{[1
]}

Moreau, Emmanuelle ^{[1
]}

Bonnet, Sarah ^{[2
]}

Plantard, Olivier ^{[3
]}

Malandrin, Laurence ^{[3
]}

机构：

[1] Ecole Natl Vet, ENVN, UMR BIOEPAR 1300, F-44307 Nantes 03, France

[2] ENVA, INRA, UMR BIPAR, F-94700 Maisons Alfort, France

[3] ENVN, INRA, UMR BIOEPAR 1300, F-44307 Nantes 03, France

来源：

VETERINARY RESEARCH | 2009年 / 40卷 / 02期

关键词：

Babesia; transmission; persistence; vertebrate host; tick host; MEROZOITE SURFACE-ANTIGEN-2 PROTEINS; RHOPTRY-ASSOCIATED PROTEIN-1; NITRIC-OXIDE PRODUCTION; NECROSIS-FACTOR-ALPHA; IXODES-RICINUS; ANTIGENIC VARIATION; SALIVARY-GLANDS; MOLECULAR CHARACTERIZATION; IN-VITRO; TRANSOVARIAL TRANSMISSION;

D O I：

10.1051/vetres/2009020

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

Babesia, the causal agent of babesiosis, are tick-borne apicomplexan protozoa. True babesiae (Babesia genus sensu stricto) are biologically characterized by direct development in erythrocytes and by transovarial transmission in the tick. A large number of true Babesia species have been described in various vertebrate and tick hosts. This review presents the genus then discusses specific adaptations of Babesia spp. to their hosts to achieve efficient transmission. The main adaptations lead to long-lasting interactions which result in the induction of two reservoirs: in the vertebrate host during low long-term parasitemia and throughout the life cycle of the tick host as a result of transovarial and transstadial transmission. The molecular bases of these adaptations in vertebrate hosts are partially known but few of the tick-host interaction mechanisms have been elucidated.

引用

页数：18

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