Memory lateralization in medial temporal lobe epilepsy assessed by functional MRI

被引:144
作者
Golby, AJ
Poldrack, RA
Illes, J
Chen, D
Desmond, JE
Gabrieli, JDE
机构
[1] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Neurosurg, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA
[4] Stanford Univ, Dept Neurol, Stanford, CA 94305 USA
[5] Stanford Univ, Program Neurosci, Stanford, CA 94305 USA
关键词
epilepsy; medial temporal lobe; fMRI; memory;
D O I
10.1046/j.1528-1157.2002.20501.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: To determine the utility of functional magnetic resonance imaging (fMRI) in preoperative lateralization of memory function in patients with medial temporal lobe epilepsy (MTLE). Methods: Nine patients with MTLE underwent standard preoperative assessment including video-EEG and intracarotid amytal testin g (IAT). fMRI was performed while subjects encoded four types of stimuli (patterns, faces, scenes, and words). Activation maps were created for each subject representing areas more active for novel than for repeated stimuli. Regions of interest were drawn around the MTL in individual subjects, suprathreshold voxels were counted, and an asymmetry index was calculated. Results: In eight of nine subjects, lateralization of memory encoding by fMRI was concordant with that obtained from the IAT. Group-level analysis demonstrated greater activation in the MTL contralateral to the seizure focus such that in the left MTLE group, verbal encoding engaged the right MTL, whereas in the right MTLE group, nonverbal encoding engaged the left MTL. Conclusions: fMRI is a valid tool for assessing of memory lateralization in patients with MTLE and may therefore allow noninvasive preoperative evaluation of memory lateralization. FMRI revealed that memory encoding may be reorganized to the contralateral MTL in patients with MTLE.
引用
收藏
页码:855 / 863
页数:9
相关论文
共 45 条
[41]  
TALAIRACH J, CO PLANAR ATLAS HUMA
[42]  
Taylor L B, 1969, Clin Neurosurg, V16, P269
[43]   MRI HIPPOCAMPAL VOLUMES AND MEMORY FUNCTION BEFORE AND AFTER TEMPORAL LOBECTOMY [J].
TRENERRY, MR ;
JACK, CR ;
IVNIK, RJ ;
SHARBROUGH, FW ;
CASCINO, GD ;
HIRSCHORN, KA ;
MARSH, WR ;
KELLY, PJ ;
MEYER, FB .
NEUROLOGY, 1993, 43 (09) :1800-1805
[44]   Novelty and familiarity activations in PET studies of memory encoding and retrieval [J].
Tulving, E ;
Markowitsch, HJ ;
Craik, FIM ;
Habib, R ;
Houle, S .
CEREBRAL CORTEX, 1996, 6 (01) :71-79
[45]   THE WAIS AS A LATERALIZING AND LOCALIZING DIAGNOSTIC INSTRUMENT - A STUDY OF 656 PATIENTS WITH UNILATERAL CEREBRAL-LESIONS [J].
WARRINGTON, EK ;
JAMES, M ;
MACIEJEWSKI, C .
NEUROPSYCHOLOGIA, 1986, 24 (02) :223-239