Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors

被引：44

作者：

Campos, MA

Gazzinelli, RT

机构：

[1] Fiocruz MS, Ctr Pesquisas Rene Rachou, Immunopathol Lab, BR-30190002 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil

来源：

MEDIATORS OF INFLAMMATION | 2004年 / 13卷 / 03期

关键词：

Trypanosoma cruzi; Toll-like receptors; host defense; innate immune response; inflammation; glycosylphosphatidylinositol;

D O I：

10.1080/09511920410001713565

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TRYPANOSOMA cruzi is the etiologic agent of Chagas' disease, a parasitic disease of enormous importance in Latin America. Herein we review the studies that revealed the receptors from innate immunity that are involved in the recognition of this protozoan parasite. We showed that the recognition of T. cruzi and its components occurs through Toll- like receptors ( TLR) 2/ CD14. Further, we showed in vivo the importance of the myeloid differentiation factor ( MyD88), an adapter protein essential for the function of TLRs, in determining the parasitemia and mortality rate of mice infected with T. cruzi. We also discuss the implications of these findings in the pathophysiology of Chagas' disease.

引用

收藏

页码：139 / 143

页数：5

相关论文

共 38 条

[31] A family of human receptors structurally related to Drosophila Toll [J].

Rock, FL ;

Hardiman, G ;

Timans, JC ;

Kastelein, RA ;

Bazan, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) :588-593

[32] Requirement of mitogen-activated protein kinases and IκB phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial lipopolysaccharide [J].

Ropert, C ;

Almeida, IC ;

Closel, M ;

Travassos, LR ;

Ferguson, MAJ ;

Cohen, P ;

Gazzinelli, RT .

JOURNAL OF IMMUNOLOGY, 2001, 166 (05) :3423-3431

[33] Toll-like receptors in health and disease: Complex questions remain [J].

Sabroe, I ;

Read, RC ;

Whyte, MKB ;

Dockrell, DH ;

Vogel, SN ;

Dower, SK .

JOURNAL OF IMMUNOLOGY, 2003, 171 (04) :1630-1635

[34] DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T-brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide [J].

Shoda, LKM ;

Kegerreis, KA ;

Suarez, CE ;

Roditi, I ;

Corral, RS ;

Bertot, GM ;

Norimine, J ;

Brown, WC .

INFECTION AND IMMUNITY, 2001, 69 (04) :2162-2171

[35] Toll-like receptors [J].

Takeda, K ;

Kaisho, T ;

Akira, S .

ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :335-376

[36] Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components [J].

Takeuchi, O ;

Hoshino, K ;

Kawai, T ;

Sanjo, H ;

Takada, H ;

Ogawa, T ;

Takeda, K ;

Akira, S .

IMMUNITY, 1999, 11 (04) :443-451

[37] Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism [J].

Werts, C ;

Tapping, RI ;

Mathison, JC ;

Chuang, TH ;

Kravchenko, V ;

Saint Girons, I ;

Haake, DA ;

Godowski, PJ ;

Hayashi, F ;

Ozinsky, A ;

Underhill, DM ;

Kirschning, CJ ;

Wagner, H ;

Aderem, A ;

Tobias, PS ;

Ulevitch, RJ .

NATURE IMMUNOLOGY, 2001, 2 (04) :346-352

[38] Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling [J].

Zhang, HF ;

Tay, PN ;

Cao, WP ;

Li, W ;

Lu, JH .

FEBS LETTERS, 2002, 532 (1-2) :171-176

← 1 2 3 4 →