Review: The Role of Neural Crest Cells in the Endocrine System

被引:34
作者
Adams, Meghan Sara [1 ]
Bronner-Fraser, Marianne [1 ]
机构
[1] CALTECH, Pasadena, CA 91125 USA
关键词
QUAIL-CHICK CHIMERAS; THYROID-C CELLS; GENE REGULATORY NETWORK; INVITRO CLONAL ANALYSIS; HIPPEL-LINDAU-SYNDROME; CANCER STEM-CELLS; SELF-RENEWAL; EPI-NCSC; IN-VITRO; EXTRAADRENAL PARAGANGLIOMA;
D O I
10.1007/s12022-009-9070-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The neural crest is a pluripotent population of cells that arises at the junction of the neural tube and the dorsal ectoderm. These highly migratory cells form diverse derivatives including neurons and glia of the sensory, sympathetic, and enteric nervous systems, melanocytes, and the bones, cartilage, and connective tissues of the face. The neural crest has long been associated with the endocrine system, although not always correctly. According to current understanding, neural crest cells give rise to the chromaffin cells of the adrenal medulla, chief cells of the extra-adrenal paraganglia, and thyroid C cells. The endocrine tumors that correspond to these cell types are pheochromocytomas, extra-adrenal paragangliomas, and medullary thyroid carcinomas. Although controversies concerning embryological origin appear to have mostly been resolved, questions persist concerning the pathobiology of each tumor type and its basis in neural crest embryology. Here we present a brief history of the work on neural crest development, both in general and in application to the endocrine system. In particular, we present findings related to the plasticity and pluripotency of neural crest cells as well as a discussion of several different neural crest tumors in the endocrine system.
引用
收藏
页码:92 / 100
页数:9
相关论文
共 143 条
[31]  
DILAURO R, 2001, ENDOCRINOLOGY
[32]   INVITRO CLONAL ANALYSIS OF PROGENITOR-CELL PATTERNS IN DORSAL-ROOT AND SYMPATHETIC-GANGLIA OF THE QUAIL EMBRYO [J].
DUFF, RS ;
LANGTIMM, CJ ;
RICHARDSON, MK ;
SIEBERBLUM, M .
DEVELOPMENTAL BIOLOGY, 1991, 147 (02) :451-459
[33]   Malignant pheochromocytoma: current status and initiatives for future progress [J].
Eisenhofer, G ;
Bornstein, SR ;
Brouwers, FM ;
Cheung, NKV ;
Dahia, PL ;
de Krijger, RR ;
Giordano, TJ ;
Greene, LA ;
Goldstein, DS ;
Lehnert, H ;
Manger, WM ;
Maris, JM ;
Neumann, HPH ;
Pacak, K ;
Shulkin, BL ;
Smith, DI ;
Tischler, AS ;
Young, WF .
ENDOCRINE-RELATED CANCER, 2004, 11 (03) :423-436
[34]   Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome [J].
Eisenhofer, G ;
Huynh, TT ;
Pacak, K ;
Brouwers, FM ;
Walther, MM ;
Linehan, WM ;
Munson, PJ ;
Mannelli, M ;
Goldstein, DS ;
Elkahloun, AG .
ENDOCRINE-RELATED CANCER, 2004, 11 (04) :897-911
[35]   MIGRATORY PATHWAYS OF HNK-1-IMMUNOREACTIVE NEURAL CREST CELLS IN THE RAT EMBRYO [J].
ERICKSON, CA ;
LORING, JF ;
LESTER, SM .
DEVELOPMENTAL BIOLOGY, 1989, 134 (01) :112-118
[36]  
FONTAINE J, 1977, J EMBRYOL EXP MORPH, V41, P209
[37]   MULTISTEP MIGRATION OF CALCITONIN CELL PRECURSORS DURING ONTOGENY OF THE MOUSE PHARYNX [J].
FONTAINE, J .
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1979, 37 (01) :81-92
[38]   Developmental origin of shark electrosensory organs [J].
Freitas, R ;
Zhang, GJ ;
Albert, JS ;
Evans, DH ;
Cohn, MJ .
EVOLUTION & DEVELOPMENT, 2006, 8 (01) :74-80
[39]  
Funahashi J, 1999, DEV GROWTH DIFFER, V41, P59
[40]   Genomic analysis of neural crest induction [J].
Gammill, LS ;
Bronner-Fraser, M .
DEVELOPMENT, 2002, 129 (24) :5731-5741