The neurobiology of appetite: hunger as addiction

被引：71

作者：

Dagher, A. ^{[1
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, Dept Neurol, Montreal, PQ H3A 2B4, Canada

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2009年 / 33卷

基金：

加拿大健康研究院;

关键词：

dopamine; striatum; amygdala; insula; orbitofrontal cortex; HUMAN OBESITY; REWARD; FOOD; DOPAMINE; BRAIN; BEHAVIOR; RECEPTOR; COCAINE; LEPTIN; BODY;

D O I：

10.1038/ijo.2009.69

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is now being recognized as a neurobehavioral disorder. Although the view of appetite as an addiction to food is controversial, there are useful lessons to be learned from the neuroscience of addiction for understanding obesity. The speakers in this symposium all addressed different aspects of the neurobiology of feeding and obesity. In this overview and the associated reviews, the behavioral, genetic and neural factors that promote over-eating in animals and humans are discussed. International Journal of Obesity (2009) 33, S30-S33; doi: 10.1038/ijo.2009.69

引用

页码：S30 / S33

页数：4

共 37 条

[11] Food reward in the absence of taste receptor signaling
de Araujo, Ivan E.
Oliveira-Maia, Albino J.
Sotnikova, Tatyana D.
Gainetdinov, Raul R.
Caron, Marc G.
Nicolelis, Miguel A. L.
Simon, Sidney A.
[J]. NEURON, 2008, 57 (06) : 930 - 941
[12] Neural ensemble coding of satiety states
de Araujo, Ivan E.
Gutierrez, Ranier
Oliveira-Maia, Albino J.
Pereira, Antonio, Jr.
Nicolelis, Miguel A. L.
Simon, Sidney A.
[J]. NEURON, 2006, 51 (04) : 483 - 494
[13] Persistence of abnormal neural responses to a meal in postobese individuals
DelParigi, A
Chen, K
Salbe, AD
Hill, JO
Wing, RR
Reiman, EM
Tataranni, PA
[J]. INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 (03) : 370 - 377
[14] DICHIARA G, 1988, P NATL ACAD SCI USA, V85, P5274
[15] Genetic factors in human obesity
Farooqi, I. S.
O'Rahilly, S.
[J]. OBESITY REVIEWS, 2007, 8 : 37 - 40
[16] Leptin regulates striatal regions and human eating Behavior
Farooqi, I. Sadaf
Bullmore, Edward T.
Keogh, Julia
Gillard, Jonathan
O'Rahilly, Stephen
Fletcher, Paul C.
[J]. SCIENCE, 2007, 317 (5843) : 1355 - 1355
[17] The specificity of restrained versus unrestrained eaters' responses to food cues: general desire to eat, or craving for the cued food?
Fedoroff, I
Polivy, J
Herman, CP
[J]. APPETITE, 2003, 41 (01) : 7 - 13
[18] Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat
Figlewicz, DP
Evans, SB
Murphy, J
Hoen, M
Baskin, DG
[J]. BRAIN RESEARCH, 2003, 964 (01) : 107 - 115
[19] The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
Fredriksson, Robert
Hagglund, Maria
Olszewski, Pawel K.
Stephansson, Olga
Jacobsson, Josefin A.
Olszewska, Agnieszka M.
Levine, Allen S.
Lindblom, Jonas
Schioth, Helgi B.
[J]. ENDOCRINOLOGY, 2008, 149 (05) : 2062 - 2071
[20] Leptin regulation of the mesoaccumbens dopamine pathway
Fulton, Stephanie
Pissios, Pavlos
Manchon, Ramon Pinol
Stiles, Linsey
Frank, Lauren
Pothos, Emmanuel N.
Maratos-Flier, Eleftheria
Flier, Jeffrey S.
[J]. NEURON, 2006, 51 (06) : 811 - 822

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