Transbilayer complementarity of phospholipids. A look beyond the fluid mosaic model

被引：36

作者：

Zhang, JB ^{[1
]}

Jing, BW ^{[1
]}

Tokutake, N ^{[1
]}

Regen, SL ^{[1
]}

机构：

[1] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 35期

关键词：

D O I：

10.1021/ja046892a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lipid-lipid interactions across a phospholipid bilayer were probed by measuring the nearest-neighbor preferences of exchangeable phospholipid monomers derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) in the presence of nonexchangeable DMPE- or DSPE-based dimers. Each of these permanent dimers promoted homophospholipid association to the same extent, whereas the corresponding nonexchangeable monomers were without effect. These results support a model in which the longer phospholipids in one monolayer leaflet preferentially associate with shorter ones in the adjoining monolayer. Such transbilayer complementarity is likely to play an important role in stabilizing biological membranes and also in promoting a compositional interdependence of their two lipid leaflets. Copyright © 2003 American Chemical Society.

引用

页码：10856 / 10857

页数：2

共 14 条

[1] Cell biology - A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains [J].