Revisiting the role of heterochromatin protein 1 in DNA repair

被引：21

作者：

Ball, Alexander R., Jr. ^{[1
]}

Yokomori, Kyoko ^{[1
]}

机构：

[1] Univ Calif Irvine, Sch Med, Dept Biol Chem, Irvine, CA 92697 USA

来源：

JOURNAL OF CELL BIOLOGY | 2009年 / 185卷 / 04期

关键词：

HP1; PROTEINS; CELLS; DYNAMICS; HP1-BETA; SITES;

D O I：

10.1083/jcb.200904033

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Heterochromatin protein 1 (HP1) is a conserved factor critical for heterochromatin organization and gene silencing. It is recruited to chromatin by its direct interaction with H3K9me (methylated lysine 9 residue of histone H3), an epigenetic mark for silenced chromatin. Now, Luijsterburg et al. (Luijsterburg, M.S., C. Dinant, H. Lans, J. Stap, E. Wiernasz, S. Lagerwerf, D.O. Warmerdam, M. Lindh, M. C. Brink, J. W. Dobrucki, et al. 2009. J. Cell Biol. 185: 577-586) reveal a new H3K9me-independent role for HP1 in the DNA damage response, which is distinct from the one recently reported by Ayoub et al. (Ayoub, N., A.D. Jeyasekharan, J. A. Bernal, and A. R. Venkitaraman. 2008. Nature. 453: 682-686).

引用

页码：573 / 575

页数：3

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