Issues in the meta-analysis of cluster randomized trials

被引：377

作者：

Donner, A ^{[1
]}

Klar, N

机构：

[1] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON N6A 5C1, Canada

[2] Canc Care Ontario, Div Prevent Oncol, Toronto, ON M5G 2L7, Canada

来源：

STATISTICS IN MEDICINE | 2002年 / 21卷 / 19期

关键词：

community trials; intraclass correlation; clustering; correlated binary data;

D O I：

10.1002/sim.1301

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Meta-analyses involving the synthesis of evidence from cluster randomization trials are being increasingly reported. These analyses raise challenging methodologic issues beyond those raised by meta-analyses which include only individually randomized trials. In this paper we review and comment on a selected number of these issues, including problems of study heterogeneity, difficulties in estimating design effects from individual trials and the choice of statistical methods. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：2971 / 2980

页数：10

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