Neural representation of behavioral outcomes in the orbitofrontal cortex

被引:50
作者
Mainen, Zachary F. [1 ]
Kepecs, Adam [2 ]
机构
[1] Inst Gulbenkian Ciencias, Champalimaud Neurosci Programme, P-2781901 Oeiras, Portugal
[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
关键词
PREFRONTAL CORTEX; NEURONAL-ACTIVITY; ENCODES RESPONSE; DECISION-MAKING; REWARD; POPULATION; UNCERTAINTY; INFORMATION; PREFERENCE; COMPUTATION;
D O I
10.1016/j.conb.2009.03.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The orbitofrontal cortex (OFC) is important in processing rewards and other behavioral outcomes. Here, we review from a computational perspective recent progress in understanding this complex function. OFC neurons appear to represent abstract outcome values, which may facilitate the comparison of options, as well as concrete outcome attributes, such as flavor or location, which may enable predictive cues to access current outcome values in the face of dynamic modulation by internal state, context and learning. OFC can use reinforcement learning to generate outcome predictions; it can also generate outcome predictions using other mechanisms, including the evaluation of decision confidence or uncertainty. OFC neurons encode not only the mean expected outcome but also the variance, consistent with the idea that OFC uses a probabilistic population code to represent outcomes. We suggest that further attention to the nature of its representations and algorithms will be critical to further elucidating OFC function.
引用
收藏
页码:84 / 91
页数:8
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