Over expression of circulating miR-155 predicts prognosis in diffuse large B-cell lymphoma

被引：41

作者：

Ahmadvand, Mohammad ^{[1
,2
,3
]}

Eskandari, Mahsa ^{[4
]}

Pashaiefar, Hossein ^{[1
]}

Yaghmaie, Marjan ^{[1
]}

Manoochehrabadi, Saba ^{[5
]}

Khakpour, Golnaz ^{[6
]}

Sheikhsaran, Fatemeh ^{[1
]}

Zohour, Mostafa Montazer ^{[7
]}

机构：

[1] Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran

[2] Cell Therapy & Hematopoiet Stem Cell Transplantat, Tehran, Iran

[3] Univ Tehran Med Sci, Hematol Malignancies Res Ctr, Tehran, Iran

[4] Islamic Azad Univ, Pharmaceut Sci Branch, Tehran, Iran

[5] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[6] Iran Univ Med Sci, Fac Med, Dept Med Genet & Mol Biol, Tehran, Iran

[7] Zahedan Univ Med Sci, Genet Noncommunicable Dis Res Ctr, Zahedan, Iran

来源：

LEUKEMIA RESEARCH | 2018年 / 70卷

关键词：

miR-155; Diffuse large B-cell lymphoma; Prognosis; MECHANISMS; MICRORNAS; TUMOR;

D O I：

10.1016/j.leukres.2018.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Introduction: The expression patterns of microRNAs in plasma are involved in potential biomarkers for several diseases. The goal of this study was to explore the expression level of miR-155 in diffuse large B-cell lymphoma (DLBCL) and its clinical significance. Materials and methods: We used qRT-PCR to assess the peripheral blood plasma of 40 DLBCL patients for the expression of miRNA-155. The median of miR-155 expression divided the DLBCL patients into miR-155 low-expression (miR-155(low)) and miR-155 high-expression (miR-155(high)) groups. Results and discussion: We found that plasma miR-155 expression was significantly up-regulated in patients with DLBCL (median expression value: 4.29, range: 1.52-27.86) compared to healthy individuals (median expression value: 2.14, range: 0.29-10.56, P < 0.002). Moreover, DLBCL cases with an elevated level of miR-155 had shorter overall survival (median 9 vs. 13 months, P=0.043) than those with a lower miR-155 expression.

引用

页码：45 / 48

页数：4

共 15 条

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MicroRNAs Are Independent Predictors of Outcome in Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP [J].