Air-stable PinP(O)H as preligand for palladium-catalyzed Kumada couplings of unactivated tosylates

被引：150

作者：

Ackermann, Lutz ^{[1
]}

Althammer, Andreas ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 16期

关键词：

D O I：

10.1021/ol061116o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Air-stable and easily accessible PinP(O)H enables highly efficient palladium-catalyzed Kumada cross-coupling reactions of aryl tosylates. The in situ generated catalyst proved applicable not only to electron-rich and electron-poor carbocyclic tosylates but also to heterocyclic tosylates, such as pyridine and quinoline derivatives. The results described herein constitute the first use of air-stable secondary phosphine oxides as preligands for transition-metal-catalyzed coupling reactions between organometallic species and tosylates.

引用

页码：3457 / 3460

页数：4

共 31 条

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