A highly active catalyst for Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds

被引：341

作者：

Billingsley, Kelvin L. ^{[1
]}

Anderson, Kevin W. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 21期

关键词：

amines; boronic acids; cross-coupling; heteroaryl halides; Suzuki-Miyaura reaction;

D O I：

10.1002/anie.200600493

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Unprecedented activity: Catalysts derived from Pd and bulky dialkylphosphinobiaryl ligands are shown to be highly stable and active in Suzuki-Miyaura reactions of heteroaryl halides and heteroaryl boronic acids/esters (e.g., 3-or 4-pyridine, indole, and N-protected pyrrole derivatives). Furthermore, this catalyst system is not inhibited by the presence of highly basic aminopyridines or aminopyrimidines. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：3484 / 3488

页数：5

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