An efficient and cost-effective synthesis of 2-phenyl-3-aminopyridine

被引：43

作者：

Caron, S ^{[1
]}

Massett, SS ^{[1
]}

Bogle, DE ^{[1
]}

Castaldi, MJ ^{[1
]}

Braish, TF ^{[1
]}

机构：

[1] Pfizer Inc, Global Res & Dev, Chem Res & Dev, Groton, CT 06340 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2001年 / 5卷 / 03期

关键词：

D O I：

10.1021/op000227e

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis of 2-phenyl-3-aminopyridine, a key intermediate in the preparation of 2-phenyl-3-aminopiperidine, from 2-chloro-3-aminopyridine is described using an imine as a protecting group for an aminopyridine, The in situ protection of 2-chloro-3-aminopyridine with benzaldehyde followed by Suzuki coupling with phenylboronic acid and subsequent acid hydrolysis provided the titled compound in a single, high-yielding step from inexpensive and commercially available starting materials.

引用

页码：254 / 256

页数：3

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