Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

被引：149

作者：

Cheung, Grace W. C. ^{[1
,2
]}

Kokorovic, Andrea ^{[1
,2
]}

Lam, Carol K. L. ^{[1
,2
]}

Chari, Madhu ^{[1
,2
]}

Lam, Tony K. T. ^{[1
,2
,3
]}

机构：

[1] Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON M5G 1L7, Canada

[2] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada

[3] Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada

来源：

CELL METABOLISM | 2009年 / 10卷 / 02期

基金：

加拿大健康研究院;

关键词：

FOOD-INTAKE; BINDING-SITES; AFFERENT-FIBERS; FATTY-ACIDS; OLETF RATS; RECEPTOR; BRAIN; INSULIN; OBESITY; HUMANS;

D O I：

10.1016/j.cmet.2009.07.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cholecystokinin (CCK) is a peptide hormone that is released from the gut in response to nutrients such as lipids to lower food intake. Here we report that a primary increase of CCK-8, the biologically active form of CCK, in the duodenum lowers glucose production independent of changes in circulating insulin levels. Furthermore, we show that duodenal CCK-8 requires the activation of the gut CCK-A receptor and a gut-brain-liver neuronal axis to lower glucose production. Finally, duodenal CCK-8 fails to lower glucose production in the early onset of high-fat diet-induced insulin resistance. These findings reveal a role for gut CCK that lowers glucose production through a neuronal network and suggest that intestinal CCK resistance may contribute to hyperglycemia in response to high-fat feeding.

引用

页码：99 / 109

页数：11

共 43 条

[21] EFFECT OF A LOW-DOSE OF INTRADUODENAL FAT ON SATIETY IN HUMANS - STUDIES USING THE TYPE-A CHOLECYSTOKININ RECEPTOR ANTAGONIST LOXIGLUMIDE [J].