The nuclear envelope LEM-domain protein emerin

被引：129

作者：

Berk, Jason M. ^{[1
]}

Tifft, Kathryn E. ^{[1
]}

Wilson, Katherine L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21218 USA

来源：

NUCLEUS | 2013年 / 4卷 / 04期

基金：

美国国家卫生研究院;

关键词：

emerin; Emery-Dreifuss muscular dystrophy; GAGE cancer-testis antigen; laminopathy; LEM-domain; nuclear envelope; nucleoskeleton; O-GlcNAc transferase; barrier-to-autointegration factor; Nestor-Guillermo progeria; DREIFUSS MUSCULAR-DYSTROPHY; TO-AUTOINTEGRATION FACTOR; CELL-CYCLE PROGRESSION; PROMOTING TRANSCRIPTIONAL REPRESSOR; METAL AFFINITY-CHROMATOGRAPHY; ACETYLGLUCOSAMINE O-GLCNAC; MEMBRANE-PROTEIN; TYROSINE PHOSPHORYLATION; PHOSPHOPROTEOME ANALYSIS; IN-VITRO;

D O I：

10.4161/nucl.25751

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge-biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease-is available. This review summarizes emerin and its emerging roles in nuclear "lamina" structure, chromatin tethering, gene regulation, mitosis, nuclear assembly, development, signaling and mechano-transduction. We also highlight many open questions, exploration of which will be critical to understand how this intriguing nuclear membrane protein and its "family" influence the genome.

引用

页码：298 / 314

页数：17

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